Lately I have not had a chance to stay on top of the updates that are getting released in SharePoint, but I definitely wanted to let everyone know about the following issue related to the October Cumulative Update.
You can read more about on the SharePoint Team Blog here:
Several users have reported that it causes issues with the User Profile Synchronization in 2010. So take heed! If you have applied this, beware!!
For those of you currently on 2007, there does not seem to be any issues with the CU at this time.